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KMID : 0352119890050020123
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Journal of Kyung Hee University
1989 Volume.5 No. 2 p.123 ~ p.127
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A CLINICAL STUDY ON ANTIANXIETY EFFECTS OF ETHYI LOFLAZEPATE(VICTAN^(®))
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Chang Hwan-Il
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Abstract
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The authors conducted a clinical study of the antianxiety c ffects of ethyl loflazepate (4 mg one single evening dose) on Korean adult neurotics.
Th! subjects were 30 outpatient neurotics whose main symp tom was anxiety and who came to the Department of N, uropsychiatry of Kyung Hee University Hospital from. February 4 to July 18, 1988. Their sex ratio was 1 male to 4 females, average age 3610.97, average weight 559.15 kg and average height 1617.71 cm. They were diagnosed as anxious episode on background of hysteria (33%), anxious episode on background of hypochondria (30%) and the others at lesser percent-ages, in our arbitrary classification.
Each patient was given ethyl loflazepate 4 mg per a day, in one single evening dose, for a duration of 3-week 3 follow-up. Clinical response was checked three times: before treatment, 1-2 weeks later and at the end of 3 weeks, using the Hamilton Anxiety Scale.
Th ~ results obtained can be summarized as follows:
1) knxiety symptoms, as rated by the Hamilton Anxi !ty Scale, were markedly reduced.: before treatment: 31.04.34; after 1-2 weeks, 12.87.48; and in the 3rd N+eek, 8.95.41.
2) n patients (86.7%) treated with ethyl loflazepate at a lower dosage (4 mg or less), the antianxiety effects were documented as early as the first week of treatment.
3)>ide effects were drowsiness, sleepiness, dizziness and ;,,eneral weakness, in that order. They appeared rather mildly during the early treatment period and toler; ince soon devloped.
4) Investigators´ final evaluations on the antianxiety effects, the safety and the use of one single evening dose were excellent.
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KEYWORD
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